It truly depends on the school. You should check out each of the schools' websites for the specific requirements since each school is a little different. If the websites do not answer your questions, then call each school and talk to someone in admissions for guidance.
I received my bachelor's in business 15 years ago. I took calculus 1 & 2 as well as gchem 20 years ago. For some of the schools - like UCSF and Texas - this was fine. For a few other schools, I needed to take all of their required science courses in the previous 5 years, including the 3 courses that i took 20 years ago. Still other schools - like Colorado and UNC - said that I did not need to retake those 3 particular courses since I had completed more advanced science courses in the past 5 years.