Curious as to if any of you are/have prescribed ivermectin for covid? We have one doc in our shop that is and he gets made fun of by others. He even tried to push our pharmacy into allowing him to use it in house - but obviously got push back. I have seen the other docs mocking it while sitting 5 feet from him, then him trying to justifyn its use. it is comical and a little sad all at once.
When I came down with Covid, I took Hydroxychloroquine, Azithromycin, Zinc, and Asprin. I began treatment 24 hours after I began to have a fever+rigors and I noticed a 2% drop in my SpO2. This was at a time when Regenron was not available and PCR test results were taking a week or more to come back and so I started my treatment based on symptoms alone without a positive test result. Did the same thing for my wife after she had a rapid antigen test.
In both cases I waited to see if we spiked fevers as a proxy for significant systemic inflammatory response, Her course paralleled mine.
In my opinion, that combination worked quite well, pretty much stopping the progression of clinical symptoms within 12 hours after initiation of treatment and putting me on a path to recovery. I was fine 2 days after stopping treatment. One could say that this was simple coincidence, and that the medications did not modify the disease course. To that I would say, first take a look at results from the study from Henry Ford. Second, in this situation, the drop in SpO2 would be indicative of lung involvement, and obviously going down the hypoxia, respiratory failure, ARDS, intubation road is something no one wants to do. Would that 2% drop have just stopped without treatment? Would it have dropped a couple of more points and recovered? Since we couldn't clone ourselves and use that as a control, we will never objectively know...but SOMETHING certainly changed the clinical course. With it's chronological proximity to starting treatment, I would say the answer would not be "a tincture of time".
In my opinion the concept for early oral outpatient treatment combines medicines that work as cytokine inhibitors, inhibitors of viral replication, tylenol to address fever, and something to try and reduce the risk of clotting either by disrupting platelet activity or the coagulation cascade (an Argentine study tried using Aspirin and Lovenox for this).
I would have prescribed the Henry Ford cocktail + Aspirin for some at risk patients early in their disease course had politicians in the state I practiced ordered pharmacies not to fill prescriptions for it.
The those who support Ivermectin use observational data (which unfortunately does not differentiate between correlation and causation and thus may not be reliable) and the fact that in-vitro, ivermectin has some activity in the first two categories. Does it have a clinical effect? Who knows. Does it cause harm when taken in the right formulation and at the right dose? Not according to what I've seen so far. Is it some sort of witch-doctor's brew that's absurd at first look? Hardly.
It still surprises me that some are taking a diagnostic and treatment approach that says "You have Covid, go home and come back if you need Oxygen."