Use all the free resources available to you from SDN: articles, guides, expert advising, forums discussions, and school research.
I’m just glad we can save some monkeys, so when all humans die off we can evolve back to this point again.Small bit of hope. 8 monkeys received a vaccine. Later, they couldn't be infected with Covid, whereas 4 controls could be. Doesn't mean it will translate in humans but still.
Science | AAAS
www.sciencemag.org
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
I'm missing the action!! I figure I would revisit my favorite old forums. I want to add my 2 cents so no flaming please :- Let me add a few things: No matter what you believe your government as a whole has let down the medical community. (Left and Right) The data/true numbers are hard to say. HOWEVER: the virus is highly virulent/contagious but NOT highly deadly. The worst places are obviously in big cities due to population density (gee wiz) Despite whatever you guys believe/feel all coronaviruses are seasonal. They are highest in winter/lowest in summer. There is a latitude effect just like flu etc. It will get better now in the Northern Hemisphere because we are moving towards summer and the UV index continues to increase. Trump is a clown but the weather/UV will now mild the storm. I suspect it will come back worse next time because it will be true winter (like when it started in China) vs our early outbreaks. Any vaccine created I suspect will not be great as all past data/attempts at making a vaccine (since SARS) have not been great. I practice anesthesia to pay my bills but I also practice other forms of medicine for health/longevity with a colleague. The medical paradigm in the U.S. IMHO is very flawed and all based on Pharmaceuticals. You have to do your own homework when it comes to treatment/studies etc... The CDC/FDA is a prime example during this pandemic. I do believe that the antimalarials and azithromycin have some positive effect WHEN and ONLY when given early in course. Do you guys know howthe virus works? The virus attacks hemoglobin (beta chain) which kicks out the heme in the red blood cells. What happens....? 02 is unable to be delivered to the mitochondria. Hmmm why is that important? Well heme synthesis first begins in the.... Mitochondria. So without getting fancy the virus knocks off the heme which decreases the rbc's ability to carry 02. Why do antimalarials work? Because covid-19 like malaria inactivates the rbcs to carry 02 to mitochondria. The blood phenotype of a Covid-19 pt somewhat resembles that of a pt infected with Malaria. Antimalarials are beneficial if given at the RIGHT time aka early. When a patient is shot up in the ICU it is to late.The time would be as patient develops symptoms but before they have respiratory failure/compromise. I'm sure you guys have read/heard about the ACE2 component of the virus right? Well chewing nicotine gum (obviously don't smoke) will decrease the expression of the ACE2 receptor component of the virus attaching/entering cell mechanism. This is a helpful treatment AGAIN early on. Not when you can are barely breathing/in the hospital. You won't hear this from the media or Faucci/Berk etc.... What about the MARIK protocol?... That is high dose iv vit c with iv thiamine +/- steroids in ICU/sepsis patients. That would be helpful too but only some big academic places are doing it... Why? IV VIt C is not very profitable for big Pharma. I'm sure you guys know the antimalarials are quite cheap/old....... not as profitable either :0 You bring up the thrombosis issue which again is not about age it's actually very simple. When heme proteins liberate iron it leads to....CLOTTING (now magnify this on the scale that it is in happening in a hospitalized covid patient) The body is releasing massive iron/Ferritin because of the continued destruction of the HGB/rbc's. You will see every hospitalized covid-19 patient with high LDH/Ferritin levels. Social distancing is one thing, but to tell people not to go outside where you can help your body generate immunity is quite silly. The virus spreads very easily indoors but outdoors in natural light lessons the effect. Generating Vitamin D via the sun will do that....Lastly whether you believe it or not this virus would have ran it course based on timing/seasonality. Here are a few links since everybody needs "evidence".
Predicted Inactivation of Viruses of Relevance to Biodefense by Solar Radiation - PMC
UV radiation from the sun is the primary germicide in the environment. The goal of this study was to estimate inactivation of viruses by solar exposure. We reviewed published reports on 254-nm UV inactivation and tabulated the sensitivities of a ...Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV - PubMed
Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by a novel coronavirus termed SARS-CoV. Due to the severity of this disease, the World Health Organization (WHO) recommends that manipulation of active viral cultures of SARS-CoV be performed in containment...Effect of ultraviolet germicidal irradiation on viral aerosols - PubMed
Ultraviolet (UV) germicidal air disinfection is an engineering method used to control the airborne transmission of pathogenic microorganisms in high-risk settings. Despite the recent emergence of respiratory viral pathogens such as SARS and avian influenza viruses, UV disinfection of pathogenic...Indoor transmission of SARS-CoV-2
Background By early April 2020, the COVID-19 pandemic had infected nearly one million people and had spread to nearly all countries worldwide. It is essential to understand where and how SARS-CoV-2 is transmitted. Methods Case reports were extracted from the local Municipal Health Commissions...www.medrxiv.org
WTF does this have to do with virus/disease epidemiology??? Seriously, you are just trolling at this point.
www.nytimes.com
www.wsj.com
Then, as I tell toddlers, USE YOUR WORDS! Are you implying that the individual pictured is going to commit another crime?
www.justice.gov
As mass coronavirus testing expands in prisons, large numbers of inmates are showing no symptoms. In four state prison systems — Arkansas, North Carolina, Ohio and Virginia — 96% of 3,277 inmates who tested positive for the coronavirus were asymptomatic, according to interviews with officials and records reviewed by Reuters. That’s out of 4,693 tests that included results on symptoms.
In four U.S. state prisons, nearly 3,300 inmates test positive for coronavirus -- 96% without symptoms
When the first cases of the new coronavirus surfaced in Ohio’s prisons, the director in charge felt like she was fighting a ghost.www.reuters.com
www.google.com
Excuse me, but could you please divide your posts into paragraphs? I feel like I'm reading "Ulysses".I'm missing the action!! I figure I would revisit my favorite old forums. I want to add my 2 cents so no flaming please :- Let me add a few things: No matter what you believe your government as a whole has let down the medical community. (Left and Right) The data/true numbers are hard to say. HOWEVER: the virus is highly virulent/contagious but NOT highly deadly. The worst places are obviously in big cities due to population density (gee wiz) Despite whatever you guys believe/feel all coronaviruses are seasonal. They are highest in winter/lowest in summer. There is a latitude effect just like flu etc. It will get better now in the Northern Hemisphere because we are moving towards summer and the UV index continues to increase. Trump is a clown but the weather/UV will now mild the storm. I suspect it will come back worse next time because it will be true winter (like when it started in China) vs our early outbreaks. Any vaccine created I suspect will not be great as all past data/attempts at making a vaccine (since SARS) have not been great. I practice anesthesia to pay my bills but I also practice other forms of medicine for health/longevity with a colleague. The medical paradigm in the U.S. IMHO is very flawed and all based on Pharmaceuticals. You have to do your own homework when it comes to treatment/studies etc... The CDC/FDA is a prime example during this pandemic. I do believe that the antimalarials and azithromycin have some positive effect WHEN and ONLY when given early in course. Do you guys know howthe virus works? The virus attacks hemoglobin (beta chain) which kicks out the heme in the red blood cells. What happens....? 02 is unable to be delivered to the mitochondria. Hmmm why is that important? Well heme synthesis first begins in the.... Mitochondria. So without getting fancy the virus knocks off the heme which decreases the rbc's ability to carry 02. Why do antimalarials work? Because covid-19 like malaria inactivates the rbcs to carry 02 to mitochondria. The blood phenotype of a Covid-19 pt somewhat resembles that of a pt infected with Malaria. Antimalarials are beneficial if given at the RIGHT time aka early. When a patient is shot up in the ICU it is to late.The time would be as patient develops symptoms but before they have respiratory failure/compromise. I'm sure you guys have read/heard about the ACE2 component of the virus right? Well chewing nicotine gum (obviously don't smoke) will decrease the expression of the ACE2 receptor component of the virus attaching/entering cell mechanism. This is a helpful treatment AGAIN early on. Not when you can are barely breathing/in the hospital. You won't hear this from the media or Faucci/Berk etc.... What about the MARIK protocol?... That is high dose iv vit c with iv thiamine +/- steroids in ICU/sepsis patients. That would be helpful too but only some big academic places are doing it... Why? IV VIt C is not very profitable for big Pharma. I'm sure you guys know the antimalarials are quite cheap/old....... not as profitable either :0 You bring up the thrombosis issue which again is not about age it's actually very simple. When heme proteins liberate iron it leads to....CLOTTING (now magnify this on the scale that it is in happening in a hospitalized covid patient) The body is releasing massive iron/Ferritin because of the continued destruction of the HGB/rbc's. You will see every hospitalized covid-19 patient with high LDH/Ferritin levels. Social distancing is one thing, but to tell people not to go outside where you can help your body generate immunity is quite silly. The virus spreads very easily indoors but outdoors in natural light lessons the effect. Generating Vitamin D via the sun will do that....Lastly whether you believe it or not this virus would have ran it course based on timing/seasonality. Here are a few links since everybody needs "evidence".
Predicted Inactivation of Viruses of Relevance to Biodefense by Solar Radiation - PMC
UV radiation from the sun is the primary germicide in the environment. The goal of this study was to estimate inactivation of viruses by solar exposure. We reviewed published reports on 254-nm UV inactivation and tabulated the sensitivities of a ...Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV - PubMed
Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by a novel coronavirus termed SARS-CoV. Due to the severity of this disease, the World Health Organization (WHO) recommends that manipulation of active viral cultures of SARS-CoV be performed in containment...Effect of ultraviolet germicidal irradiation on viral aerosols - PubMed
Ultraviolet (UV) germicidal air disinfection is an engineering method used to control the airborne transmission of pathogenic microorganisms in high-risk settings. Despite the recent emergence of respiratory viral pathogens such as SARS and avian influenza viruses, UV disinfection of pathogenic...Indoor transmission of SARS-CoV-2
Background By early April 2020, the COVID-19 pandemic had infected nearly one million people and had spread to nearly all countries worldwide. It is essential to understand where and how SARS-CoV-2 is transmitted. Methods Case reports were extracted from the local Municipal Health Commissions...
The H2-blocker may interfere with immunity somewhere. Interesting to see if there is any similar observation about H1-blockers (people with allergies).
www.wsj.com
www.statnews.com
IL6 Ab (Regeneron, Sanofi) study halted, no benefit seen.
Drug Study Halted Early for Certain Covid-19 Patients After No Benefit Seen
Regeneron and Sanofi said they will shut down part of a study exploring whether their arthritis therapy could treat certain hospitalized Covid-19 patients because the drug looked unlikely to help them.
www.ncbi.nlm.nih.gov
www.pharmaceutical-technology.com
www.wsj.com
www.bloomberg.com
Obviously. We already have a treatment like that for a respiratory virus that doesn't confer immunity, we don't have a vaccine for, and hits a certain age group disproportionately.Scott Gottlieb, former head of the U.S. Food and Drug Administration, also sounded optimistic in a recent interview with Bloomberg News, saying, “If I had to place one bet on a drug that could be available by the summer and could have activity and could have a profile that I think could change the contours of the infection, it would be the antibody approaches.”
Antibody Treatments May Be the Best Hope Against the Virus Until a Vaccine
Regeneron’s drug cocktail could be tested in humans by summer and be saving lives by fall.
At high doses the drugs might prevent the disease from progressing in hospitalized patients. At lower doses, the same antibodies could work as a prophylactic, conferring immediate but short-term immunity to doctors and other first-line responders. The company says it hopes by August it will be able to produce 200,000 prophylactic doses a month. Already infected patients might require a dose 10 times as strong; the company could make about 20,000 of those a month.
Kyratsous says the long-term goal is to make drugs with what he calls cross-reactive antibodies, which would be effective not just against this coronavirus but against others that have already emerged—and still more that are likely to.
Antibody treatments won’t eliminate the need for a vaccine. They might not work on critically ill patients. And as a prophylactic, the drug would likely have to be given every couple of months. It wouldn’t be practical to treat all high-risk people with regular antibody infusions. But the treatments might help communities return to a seminormal state until a vaccine is finally available. —
You may get lucky one day and finally be right with one of your predictions. But it still doesn’t seem like you’re able to differentiate between good data/evidence and poor/unreliable data. Everything you post is what you think may be promising or what you hope may be true. Has there been even a single RCT where an IL-6 antibody has succeeded? Not to my knowledge. They have all failed.As I have posted the most promising treatment for Covid 19 is from Regeneron. Regeneron will have monoclonal antibodies against Covid 19 by August. This treatment could be ramped up quickly to provide a real medication with high efficacy against Covid 19.
The Secret Group of Scientists and Billionaires Pushing a Manhattan Project for Covid-19
They are working to cull the world’s most promising research on the pandemic, passing on their findings to policy makers and the White House.
Mother f**^%*r...now I can’t drink coffee, chocolate or over-eat. Desperate people grasping at straws are messing with my reflux meds.
Where are you getting this pathophysiology from? Haven’t seen anything to this affect about the virus, I’d be surprised if anyone had actually suggested this detailed pathology about a virus that is so new.I'm missing the action!! I figure I would revisit my favorite old forums. I want to add my 2 cents so no flaming please :- Let me add a few things: No matter what you believe your government as a whole has let down the medical community. (Left and Right) The data/true numbers are hard to say. HOWEVER: the virus is highly virulent/contagious but NOT highly deadly. The worst places are obviously in big cities due to population density (gee wiz) Despite whatever you guys believe/feel all coronaviruses are seasonal. They are highest in winter/lowest in summer. There is a latitude effect just like flu etc. It will get better now in the Northern Hemisphere because we are moving towards summer and the UV index continues to increase. Trump is a clown but the weather/UV will now mild the storm. I suspect it will come back worse next time because it will be true winter (like when it started in China) vs our early outbreaks. Any vaccine created I suspect will not be great as all past data/attempts at making a vaccine (since SARS) have not been great. I practice anesthesia to pay my bills but I also practice other forms of medicine for health/longevity with a colleague. The medical paradigm in the U.S. IMHO is very flawed and all based on Pharmaceuticals. You have to do your own homework when it comes to treatment/studies etc... The CDC/FDA is a prime example during this pandemic. I do believe that the antimalarials and azithromycin have some positive effect WHEN and ONLY when given early in course. Do you guys know howthe virus works? The virus attacks hemoglobin (beta chain) which kicks out the heme in the red blood cells. What happens....? 02 is unable to be delivered to the mitochondria. Hmmm why is that important? Well heme synthesis first begins in the.... Mitochondria. So without getting fancy the virus knocks off the heme which decreases the rbc's ability to carry 02. Why do antimalarials work? Because covid-19 like malaria inactivates the rbcs to carry 02 to mitochondria. The blood phenotype of a Covid-19 pt somewhat resembles that of a pt infected with Malaria. Antimalarials are beneficial if given at the RIGHT time aka early. When a patient is shot up in the ICU it is to late.The time would be as patient develops symptoms but before they have respiratory failure/compromise. I'm sure you guys have read/heard about the ACE2 component of the virus right? Well chewing nicotine gum (obviously don't smoke) will decrease the expression of the ACE2 receptor component of the virus attaching/entering cell mechanism. This is a helpful treatment AGAIN early on. Not when you can are barely breathing/in the hospital. You won't hear this from the media or Faucci/Berk etc.... What about the MARIK protocol?... That is high dose iv vit c with iv thiamine +/- steroids in ICU/sepsis patients. That would be helpful too but only some big academic places are doing it... Why? IV VIt C is not very profitable for big Pharma. I'm sure you guys know the antimalarials are quite cheap/old....... not as profitable either :0 You bring up the thrombosis issue which again is not about age it's actually very simple. When heme proteins liberate iron it leads to....CLOTTING (now magnify this on the scale that it is in happening in a hospitalized covid patient) The body is releasing massive iron/Ferritin because of the continued destruction of the HGB/rbc's. You will see every hospitalized covid-19 patient with high LDH/Ferritin levels. Social distancing is one thing, but to tell people not to go outside where you can help your body generate immunity is quite silly. The virus spreads very easily indoors but outdoors in natural light lessons the effect. Generating Vitamin D via the sun will do that....Lastly whether you believe it or not this virus would have ran it course based on timing/seasonality. Here are a few links since everybody needs "evidence".
Predicted Inactivation of Viruses of Relevance to Biodefense by Solar Radiation - PMC
UV radiation from the sun is the primary germicide in the environment. The goal of this study was to estimate inactivation of viruses by solar exposure. We reviewed published reports on 254-nm UV inactivation and tabulated the sensitivities of a ...Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV - PubMed
Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by a novel coronavirus termed SARS-CoV. Due to the severity of this disease, the World Health Organization (WHO) recommends that manipulation of active viral cultures of SARS-CoV be performed in containment...Effect of ultraviolet germicidal irradiation on viral aerosols - PubMed
Ultraviolet (UV) germicidal air disinfection is an engineering method used to control the airborne transmission of pathogenic microorganisms in high-risk settings. Despite the recent emergence of respiratory viral pathogens such as SARS and avian influenza viruses, UV disinfection of pathogenic...Indoor transmission of SARS-CoV-2
Background By early April 2020, the COVID-19 pandemic had infected nearly one million people and had spread to nearly all countries worldwide. It is essential to understand where and how SARS-CoV-2 is transmitted. Methods Case reports were extracted from the local Municipal Health Commissions...
There was a paper the Chinese put out. It’s in the CCM forum under “Are we treating ARDS” I believe. Interesting stuff.
Because half of it is true, half is speculation.
Two factors we can do to manipulate gas exchange of oxygen without mechanical circulatory support: Mean airway pressure and FIO2.
If you look at a normal pressure vs time curve on a ventilator for volume control, and compare it to pressure control:
Assuming all other variables (Insp time, vent rate, PEEP) are all the same, pressure mode gives you a higher mean airway pressure for any given peak inspiratory pressure, which in turn gives you better oxygenation parameters.
The downside is that ventilation might be affected depending on the compliance of the lung, which can be attenuated by modes that use the pressure control wave form but guarantees a certain tidal volume (VC+ on covidian, Volume autoflow on drager, pressure control volume guaranteed on GE).
Looking at this, you realize there are several parameters you can manipulate to change the airway pressure: the I:E ratio can change the mean airway pressure as much as the peep.
Lastly, you can tell many of the modes can be manipulated to do the same thing. APRV (bilevel for covidian) can be achieved through pressure control and simply changing the I:E time. I used to troll people in the ICU when i dropped people off and put them on APRV mode but it's really pressure support or pressure control or I:E of 1:2.
Mastery of these different modes is vital to supporting your patient as they have increased need for oxygenation.
