I think the thing that makes a journal club/lit review really great is kind of an outside the box application of the conclusion. Hard to say exactly what to do for each article, but there's a few things to look at. Maybe start with the population. Is that the population you'd really be using the drug/therapy on, or not? For example you're probably not giving IV abx for CAP with low CURB, they'll get oral therapy and go home. Also look at inclusion/exclusions; are they purposely excluding a patient population that would often receive this kind of care, or are they reasonable exclusions? Then look at the actual interventions. Are the patients getting the standard of care in either the active or control group? Is the comparator dosed appropriately? If not, that could be a huge factor and really skew the results. It takes a pretty thorough knowledge of the topic at hand to do this sort of thing, so it will definitely take lots of time to develop.
