If you can pick two months for vacation, then take December and January off.....that's the peak of interviews. Some programs do start interviewing in mid-November, so just make sure that that month you are on a rotation where you could take a day or two off....and schedule your local interviews then if possible.
If you are a DO student, most programs start interviewing in early November and even Mid-October....so take November and December off.
I took December off for my vacation month and was able to do the Clinical Skills exam and interview a few places. November was a research elective for me so that gave me flexibility with my schedule....and I did Emergency Medicine in January so I was able to switch a couple shifts and do my local interviews then.