Not sure I can give you the whole answer you are looking for as I am only a month into 1st year at KCUMB, but I specifically chose KCUMB because of the genesis curriculum.
From what I have experienced so far, even in the one part of the curriculum that isn't that systems based (Foundations of Medicine is your starting block and it lasts 4 weeks - then you start systems with musculoskeletal), they really try to build on each others lectures and tie the material together for you. I think this is really important because on boards you are not going to be asked an "anatomy" or "biochemistry" question in isolation. You are going to be given a patient situation that has biochemical, physiological, immunological and microbiologyical data (for example) and you have to come up with the best answer to what's wrong, what drug would you give etc. I think it ties to the real world better and you are better able to assimilate things when you can see how things all interrelate.
So for Foundations of Medicine - we talked about cancer in genetics, biochemistry, pathology and immunology. You could see how all the various elements come into play when someone has cancer. In addition, we had a series of physiology lectures about the autonomic nervous system which was followed by a pharmacology lectures about the drugs that impact the ANS. Much easier to understand what a beta blocker does when you just went over what role beta receptors play in the ANS.
I don't know if this is unique to KCUMB but the support provided by the staff and the professors is unbelieveable. Several will be in an online chat room on the KCUMB website the night before a midterm / final in order to answer last minute questions. Most (all I think) have open door policies so you can go for help on anything. In addition, we were assigned a specific advisor during orientation week and lunch with them then. They then follow up with one on one lunches through out the year to make sure we're doing OK and they encourage us to contact them at any time if we have any thing we want to discuss.
I was a little concerned about security before I got to KCUMB, especially as I live at Century Towers across the street, and the neighborhood isn't the greatest. However, the security team at KCUMB is great. They keep an eye out in the morning and afternoon as students cross from CT to KCUMB. They encourage everyone to call them so they can escort you across to CT if you are alone. They are very good.
One unique area might be the focus KCUMB places on spirtuality in their training. They really want doctors they graduate to understand the spirituality requirements of their patients and well as themselves. I'm not sure I saw such a focus at any other school. You can do some digging on the KCUMB web site and in the course catalog to get a better sense of this.
Hope that helps a bit.