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question about grignards and ethers

Discussion in 'DAT Discussions' started by preDENT1210, Jul 28, 2011.

  1. Bis-GMA111

    7+ Year Member

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    if a grignard can be used to attack an epoxide, why can't it be used to attack a regular ether?
     
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  2. FROGGBUSTER

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    What kind of reaction do you think would happen between a Grignad and ether? Ring opening can occur between a Grignard and an epoxide, nothing happens between a Grignard and ether. This is why ethers are good solvents from Grignards.
     
  3. indigenoustw

    indigenoustw Am I picking my nose or showing my shaka?
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    Angle strain makes it easy for Grignard to attack epoxides. Other forms of ether are pretty stable and most are free of angle strain.
     
  4. wired202808

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    An Ether has no acidic protons for the grignard to attack.
     

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