iPad + Bluetooth keyboard/case + Notability + automatic backup to Google Drive works fantastic for me, and I think the majority of my classmates feel the same. We all have iPads as we have to take our exams on them (couple people use laptops instead but 90% use iPads for the better portability and battery life). We do have a few paper note takers. I don't think there is anybody who prints off slides though, I think the ones that hand write notes still download the pdfs and then take notes in a notebook.
I wouldn't try to go fully paper unless you feel strongly that is the only way you can learn effectively. Printing off all the course materials provided in PT school would probably be an unmanageable amount of paper in a semester where you have 6+ classes and 3 or more of them also have labs. I also find having quick digital access to all of my course materials from previous semesters to be very helpful when I need to do a quick lookup of something that is relevant to a current class, and that wouldn't be possible with paper. Services like Google Drive, One Drive, Dropbox, etc also allow you to take notes on whatever device you choose in school (ipad for me), pull them up on a different device when studying at home if desired (eg my laptop), and even pull them up on a phone if you want to do a little reading when you are out and about, sitting in a waiting room or something.
So for me, going 100% digital with course materials was the way to go. I do like having hard copies of textbooks though, but I don't usually tote them to school. With all that said, some people really feel strongly they learn better with paper. For me I learn better if I can type notes so that get things written faster and I can spend more time listening to what is being said by the teacher and less time distracted by the process of writing. But some people can write and listen at the same time better (though evidence strongly suggests true 100% multi-tasking by the brain doesn't really happen), and some say you "deep learn" better by hand writing on paper because it makes you process information more because you have to try to shorten it down to the key words.
So you'll have to think about it and weigh out the pros and cons and decide what works for you. But realistically for the amount of course materials you're going to want to have easy access to on a daily basis, it would be a
lot of paper to tote around without going at least partially digital. I guess all the PT students in the days before laptops did it and graduated just fine...but they also had to walk uphill in the snow both ways to school and use their own severed left arm as a goniometer, so they were tougher than us modern day whiny millenials.
We also get provided with a lot more slides and content then PT students of former generations did.