Well, I was told by veterinarians and professors that have seen a lot of grads get accepted and denied over the years that the second application cycle seems to be the most successful. That being said, I took a year off of school after graduating to gain more experience before I applied and *All* of my advisers told me waiting to apply was a terrible idea for my application because "the longer you are out of school, the worse it looks." One of my lors let me see some of his lor and he went so far as to bluntly point out all of the reasons I waited a year after finishing undergrad to apply the first time. He said he wanted to make sure that adcoms knew i had very practical reasons for waiting to apply so they wouldn't hold it against me. Thus, I feel like multiple application cycles work favorably to a degree, but only if you can explain what you have done to strengthen your application. I assume that they think the longer you are out of school, the less "fresh" certain materials are in your mind. And thus, the more you will have to relearn when you begin school.