Generally you send them when you've been granted a secondary or when you submit the secondary.
If you're applying to any of the schools that use AMCAS's letter service, then you will probably want to send AMCAS the letters when you submit your primary, that way they process them in time to send them to schools when/if they request them.
i was actually browsing the website and it says that AMCAS will start accepting LORs around may 14th. so we can start to submit them then, before the primary is even done.
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