Y'all, I just finished reading the kind of book where you stay up until 2 am reading it because it's sooooooo good, and then I got to the end of it and learned that it's based on a true story, and now I am SHOOK.
For a brief plot summary from GoodReads:
"Twelve-year-old Rill Foss and her four younger siblings live a magical life aboard their family’s Mississippi River shantyboat. But when their father must rush their mother to the hospital one stormy night, Rill is left in charge—until strangers arrive in force. Wrenched from all that is familiar and thrown into a Tennessee Children’s Home Society orphanage, the Foss children are assured that they will soon be returned to their parents—but they quickly realize the dark truth. At the mercy of the facility’s cruel director, Rill fights to keep her sisters and brother together in a world of danger and uncertainty.
Aiken, South Carolina, present day. Born into wealth and privilege, Avery Stafford seems to have it all: a successful career as a federal prosecutor, a handsome fiancé, and a lavish wedding on the horizon. But when Avery returns home to help her father weather a health crisis, a chance encounter leaves her with uncomfortable questions and compels her to take a journey through her family’s long-hidden history, on a path that will ultimately lead either to devastation or to redemption."
tl;dr: an "orphanage" operating in Tennessee was kidnapping kids and then selling them to wealthy families through high-priced adoptions.
The book is called When We Were Yours by Lisa Wingate and holy cow. Go read it.
Y'all, I just finished reading the kind of book where you stay up until 2 am reading it because it's sooooooo good, and then I got to the end of it and learned that it's based on a true story, and now I am SHOOK.
For a brief plot summary from GoodReads:
"Twelve-year-old Rill Foss and her four younger siblings live a magical life aboard their family’s Mississippi River shantyboat. But when their father must rush their mother to the hospital one stormy night, Rill is left in charge—until strangers arrive in force. Wrenched from all that is familiar and thrown into a Tennessee Children’s Home Society orphanage, the Foss children are assured that they will soon be returned to their parents—but they quickly realize the dark truth. At the mercy of the facility’s cruel director, Rill fights to keep her sisters and brother together in a world of danger and uncertainty.
Aiken, South Carolina, present day. Born into wealth and privilege, Avery Stafford seems to have it all: a successful career as a federal prosecutor, a handsome fiancé, and a lavish wedding on the horizon. But when Avery returns home to help her father weather a health crisis, a chance encounter leaves her with uncomfortable questions and compels her to take a journey through her family’s long-hidden history, on a path that will ultimately lead either to devastation or to redemption."
tl;dr: an "orphanage" operating in Tennessee was kidnapping kids and then selling them to wealthy families through high-priced adoptions.
The book is called When We Were Yours by Lisa Wingate and holy cow. Go read it.
Y'all, I just finished reading the kind of book where you stay up until 2 am reading it because it's sooooooo good, and then I got to the end of it and learned that it's based on a true story, and now I am SHOOK.
For a brief plot summary from GoodReads:
"Twelve-year-old Rill Foss and her four younger siblings live a magical life aboard their family’s Mississippi River shantyboat. But when their father must rush their mother to the hospital one stormy night, Rill is left in charge—until strangers arrive in force. Wrenched from all that is familiar and thrown into a Tennessee Children’s Home Society orphanage, the Foss children are assured that they will soon be returned to their parents—but they quickly realize the dark truth. At the mercy of the facility’s cruel director, Rill fights to keep her sisters and brother together in a world of danger and uncertainty.
Aiken, South Carolina, present day. Born into wealth and privilege, Avery Stafford seems to have it all: a successful career as a federal prosecutor, a handsome fiancé, and a lavish wedding on the horizon. But when Avery returns home to help her father weather a health crisis, a chance encounter leaves her with uncomfortable questions and compels her to take a journey through her family’s long-hidden history, on a path that will ultimately lead either to devastation or to redemption."
tl;dr: an "orphanage" operating in Tennessee was kidnapping kids and then selling them to wealthy families through high-priced adoptions.
The book is called When We Were Yours by Lisa Wingate and holy cow. Go read it.
Y'all, I just finished reading the kind of book where you stay up until 2 am reading it because it's sooooooo good, and then I got to the end of it and learned that it's based on a true story, and now I am SHOOK.
For a brief plot summary from GoodReads:
"Twelve-year-old Rill Foss and her four younger siblings live a magical life aboard their family’s Mississippi River shantyboat. But when their father must rush their mother to the hospital one stormy night, Rill is left in charge—until strangers arrive in force. Wrenched from all that is familiar and thrown into a Tennessee Children’s Home Society orphanage, the Foss children are assured that they will soon be returned to their parents—but they quickly realize the dark truth. At the mercy of the facility’s cruel director, Rill fights to keep her sisters and brother together in a world of danger and uncertainty.
Aiken, South Carolina, present day. Born into wealth and privilege, Avery Stafford seems to have it all: a successful career as a federal prosecutor, a handsome fiancé, and a lavish wedding on the horizon. But when Avery returns home to help her father weather a health crisis, a chance encounter leaves her with uncomfortable questions and compels her to take a journey through her family’s long-hidden history, on a path that will ultimately lead either to devastation or to redemption."
tl;dr: an "orphanage" operating in Tennessee was kidnapping kids and then selling them to wealthy families through high-priced adoptions.
The book is called When We Were Yours by Lisa Wingate and holy cow. Go read it.
Even better. I went through an audiobook phase a few years ago where I listened to three books in a row that were narrated by people with british accents
I have genuinely sadlaughed at the posts that are like "what if shorty is powerwolfing" and I'm like LOL I WISH I WERE ANYWHERE NEAR GOOD ENOUGH TO PULL THAT OFF
Instead I get to feel like I'm putting in a whole lot of work to accomplish a whole lot of suckitude but that's what PhD life feels like too so I'm used to it?
Even better. I went through an audiobook phase a few years ago where I listened to three books in a row that were narrated by people with british accents
It's called Before & After, same author along with Judy Christie
@sunshinefl I'm in a dual DVM/PhD program and in the PhD part at the moment. I'm at the part of the program where I've been in school for a REALLY long time and yet somehow am still not any sort of doctor
So, I primarily study alterations in the extracellular matrix of osteosarcoma metastases. We don't really understand why it is that when lung metastases are detectable, they don't respond to chemotherapy, and I study the interactions of our commonly used chemos with the ECM and how it prevents drug influx, both biochemically and physically. But on top of that, I'm also using forward genetic screening with the Sleeping Beauty transposon system and identified some novel genes that we think play a role in chemoresistance, which I was supposed to be validating now but since I've been sick, that's on hold.
My first 2 years of the thesis were just creating the mouse model and surgery/chemo protocols since we do our best approximation of human standard of care - amputation surgery + a 3-drug chemo regimen, and I have a minor spin-off pharmacokinetic project that resulted from that work too.
Also fun fact, Dubz and @PrincessButterCup voluntarily sat through me blabbing about my research for an hour when I was preparing for my qualifying exams (for the non-PhD peeps, quals are different by program but mine was writing 2 proposals and then a 3 hour oral exam). I fully intend to repay the favor!
So, I primarily study alterations in the extracellular matrix of osteosarcoma metastases. We don't really understand why it is that when lung metastases are detectable, they don't respond to chemotherapy, and I study the interactions of our commonly used chemos with the ECM and how it prevents drug influx, both biochemically and physically. But on top of that, I'm also using forward genetic screening with the Sleeping Beauty transposon system and identified some novel genes that we think play a role in chemoresistance, which I was supposed to be validating now but since I've been sick, that's on hold.
My first 2 years of the thesis were just creating the mouse model and surgery/chemo protocols since we do our best approximation of human standard of care - amputation surgery + a 3-drug chemo regimen, and I have a minor spin-off pharmacokinetic project that resulted from that work too.
Omg, I'm pretty sure I met you at my UMN interview a few years ago. I had a long conversation with (I'm assuming) you about your PhD research because I'm having some serious deja vu right now lol.
So, I primarily study alterations in the extracellular matrix of osteosarcoma metastases. We don't really understand why it is that when lung metastases are detectable, they don't respond to chemotherapy, and I study the interactions of our commonly used chemos with the ECM and how it prevents drug influx, both biochemically and physically. But on top of that, I'm also using forward genetic screening with the Sleeping Beauty transposon system and identified some novel genes that we think play a role in chemoresistance, which I was supposed to be validating now but since I've been sick, that's on hold.
My first 2 years of the thesis were just creating the mouse model and surgery/chemo protocols since we do our best approximation of human standard of care - amputation surgery + a 3-drug chemo regimen, and I have a minor spin-off pharmacokinetic project that resulted from that work too.
so i'm only in advanced cell bio for undergrads rn but I'm trying to wrap my brain around and understand a bit more. so is it that we suspect something on the surface/having to do with the chemistry of the cell membrane of cancer cells is resistant to chemo? it's a little out of my element since i study the metabolism of insecticides in arthropods
so i'm only in advanced cell bio for undergrads rn but I'm trying to wrap my brain around and understand a bit more. so is it that we suspect something on the surface/having to do with the chemistry of the cell membrane of cancer cells is resistant to chemo? it's a little out of my element since i study the metabolism of insecticides in arthropods
Well, we've noticed that when you treat with chemo, osteosarcomas produce a ton of matrix in response - so we looked at what's making up that matrix, and based on that, we're doing some deep dives on the genes responsible for producing that particular component to see if we can find any links. From what we can tell, its upregulation physically blocks chemo from getting into the tumor (we can show this with fluorescent microscopy), but we're still trying to tease out what signaling pathways are affected by it too.
Well, we've noticed that when you treat with chemo, osteosarcomas produce a ton of matrix in response - so we looked at what's making up that matrix, and based on that, we're doing some deep dives on the genes responsible for producing that particular component to see if we can find any links. From what we can tell, its upregulation physically blocks chemo from getting into the tumor (we can show this with fluorescent microscopy), but we're still trying to tease out what signaling pathways are affected by it too.
I study chytrid, pathogenic fungi that infect amphibians. Mainly the more recently discovered one, Bsal, that isn't in the US (yet), but my siren project is with Bd, which is endemic in some areas in the US. So far I've done work with pathogenesis, diagnostics, and a little bit of treatment exploration. But my plan for my thesis work is to investigate long-term effects of sublethal infection, especially on reproductive fitness.
I study chytrid, pathogenic fungi that infect amphibians. Mainly the more recently discovered one, Bsal, that isn't in the US (yet), but my siren project is with Bd, which is endemic in some areas in the US. So far I've done work with pathogenesis, diagnostics, and a little bit of treatment exploration. But my plan for my thesis work is to investigate long-term effects of sublethal infection, especially on reproductive fitness.
Every time interview season rolls around, I get at least 1 PM from some applicant who figures out who I am. Anonymity is overrated. Or that's what I keep telling myself b/c I'm really bad at being anonymous
Every time interview season rolls around, I get at least 1 PM from some applicant who figures out who I am. Anonymity is overrated. Or that's what I keep telling myself b/c I'm really bad at being anonymous
Every time interview season rolls around, I get at least 1 PM from some applicant who figures out who I am. Anonymity is overrated. Or that's what I keep telling myself b/c I'm really bad at being anonymous
I feel this so much hahaha I had a great time doing them and meeting applicants, but I was WIPED OUT afterward.
I always feel that way at our orientation too, I love welcoming the incoming first years and doing all the activities with them, and then at the end of the day/during free time, it's basically guaranteed that I'm off in a quiet corner somewhere with a book.
I'm the opposite of Shorty once again. I am a real extrovert. I get drained by alone time and charged up by talking to people. Hence, human internal medicine.
Not gonna lie, I didn't know what this was going to be and I had jokingly said to Z that if you posted saying NSYNC was better than Backstreet Boys (since we seem to disagree on a lot of things), I was going to change my yeet vote to you for a few minutes just out of spite.
This exchange that was moved to the sign-ups thread just made me realize I missed an entire page of posts last night on the game thread. So now I gotta go back and read that entire page. Also that is one of my favorite B99 scenes too!!
I have a spreadsheet of books I want to read and I've already realized that I almost certainly have more books on there than I could read in a natural lifespan.
I only allow myself to go to the bookstore like once every 3 months. My college town has a great one where there are $1-$5 quality books. I love it there!
Okay but HBP is my favorite bookstore, and I love going there when I am back at my parents' house. I just really love bookstores and libraries. When I was a kid, my parents stopped getting me brand-new books as gifts because I would finish 1 (or more) books in a day. So instead they got me HPB giftcards haha
PS @alleycat03 (and anyone else!) am happy to add you to my spreadsheet if you need even MOAR BOOKS for your list and if you want to add books to mine!!
I only allow myself to go to the bookstore like once every 3 months. My college town has a great one where there are $1-$5 quality books. I love it there!
PS @alleycat03 (and anyone else!) am happy to add you to my spreadsheet if you need even MOAR BOOKS for your list and if you want to add books to mine!!
PS @alleycat03 (and anyone else!) am happy to add you to my spreadsheet if you need even MOAR BOOKS for your list and if you want to add books to mine!!
