Speaking to people at MSU-COM or very recent graduates would be able to speak to this more, but being that MSU-COM is one of the best DO schools in the country, your best bet for competitive specialties (of the DO schools) would be from there I reckon. I have heard that anti-DO bias was waning a bit, but through some grapeviney talk I also heard that some local places are still continuing the anti-DO thing and favoring MD grads for residency spots. If you really want to be an interventional cardiologist and got accepted to DO schools only, i would suggest trying to find someone (younger the better, as I think an older person would speak to a bit of an outdated social discrimination milieu) who fits that profile (DO interventional cardiologist) and who can speak to any barriers they faced (If it is too hard to find that person, then that might be an unfortunate answer as well). I think the anti-DO thing is pretty dumb, personally, but it's hard to deny it exists and I think your concerns are valid and worth looking in to.
I also would advise that people's minds change A LOT in school. You've probaby heard that before, but I have seen so many people in my class evolve in what they are interested in and we aren't even on the wards yet. So what I would think was unfortunate is if you threw away an acceptance to a great medical school because you're afraid it won't offer you the ability to match in a residency/fellowship you can't guarantee you will actually have the same passion for now than you will in your fourth year. I don't know you or your background, so I apologize if this is offensive to you in any way. I am just coming from watching people match into things way different than their background or 1st year interest because something unpredictable sparked their interest down the line. So what I am saying is that getting into DO school is a great achievement, will result in you being a physician, and will allow you have a fulfilling career in medicine if you are open to the path.
Wayne is still your first choice tho, which is great! If you hear back from Wayne any time between now and the day that MSUCOM starts, then absolutely you should jump on the opportunity. But if you do not end up getting accepted, I really don't think that means you've lost out in any real ways considering the school you are already accepted to has a lot to offer.