I've worked in research at Columbia St. Lukes and Mt. Sinai School of Medicine for the past several years, lived in Harlem, had to walk around Harlem, right past where the new Touro-NY school is as part of my job, etc. I used to live/work pretty close to there and I could deal with that.
My problem is this, for a school that claims to be supporting underserved & urban medicine, from what I understand if you speak to current students & recent interviewees, the only clinical sites they have set up are not anywhere near Harlem. In other cities/towns, it is possible to have a car and commute to distance clerkships, but in Manhattan, that means you'd have to either (1) live ridiculously far from school or some of the clinical rotations in order not to double your rent, or (2) live near school but take public transportation. From what I heard, if it is correct, some rotation sites are in Staten Island, and distant parts of Queens, Brooklyn, Bronx, etc.--miserable commutes when you are overworked/overstressed. If they can guarantee you that you will be at the same site for all rotations, you could move to be close to it, but I doubt they have that much clout yet. I feel like they should have been more forthcoming about this.
To me, when a school is in Harlem and near so many hospitals, and so tiny, I just sort of assumed they would have successfully negotiated for rotations in Harlem. It doesn't sound like they did.
Accordingly, unless you get information that tells you otherwise, and unless you are ok with 2 hour public transportation to your clerkships, I would go with Touro-NV, a known entity.