Lecturers will rotate to the distance sites as well during a course. Also, you have faculty present at all of the sites during lectures. A lot of the class watches lectures from home, which are not mandatory attendance. So you can live stream or watch it later. Lecture wise, it really shouldn't make a difference. Same thing for the labs. It is live feed at the sites where the professor isn't speaking at during the lecture. Some of the student organization and student government positions that you can run for in the spring of your first year require you to be located at East Lansing. However, there are other positions open to those at the distance sites. MSUCOM does a pretty decent job at balancing out opportunities and resources at all 3 sites.
Personally, I like watching the lectures later on because you can double speed the lecture. It saves time spent watching lectures, and allows more time to study and etc.
Their are osteopathic diagnostic radiology residency programs. Can't really speak on specifics of your chances of landing a spot because that will ultimately depend on a number of factors. If you go to
http://www.opportunities.osteopathic.org/ , you can search how many osteopathic rads residency there are and their location.