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I thought about that too when I sent in my application. I talked to the associate premed adviser at my school, and she said the committee letter is sufficient for HMS. I'm still wondering if they would disregard someone's application as 'incomplete' if they don't have the required recommendations.
you can definitely get an interview without having letters from everyone you've listed on your app as research advisors/mentors/PIs, but at the interview your interviewier may notice and bring up the lack of letters failing to match up with what you've listed.
last year when i was interviewing for HST, i found out from my interviewer panel that they were missing a letter from one of my PIs and the panel wanted to see it. it turned out that my undergrad had just accidentally not attached one of my letters to my committee letter...but imagine if you had to sit there and explain why you didn't ask a certain PI for a letter haha
to be fair, neither of my NP interviewers asked to see the missing letter.