I too was accepted to all three schools, and went to second looks for Temple & Jefferson, and attended a PBL class at Drexel after my acceptance.
Here are my impressions, I hope they are helpful:
Location
Jefferson is in center city Philadelphia, which is the best part of the city. Chinatown is a few blocks away, and the area is very safe and active all the time. There are more bars and restaurants in a five block radius than you'd be able to go to even if you picked a different place every day. It's also a very professional area so there are lots of things for young professionals to do (e.g bars, clubs, etc). It is a nice mile away from the riverfront area, which is great in the summer to walk to. Temple is in one of the worst areas of the city (North Philly), and you won't live there. However, many Temple students live in center city anyway, just like where the Jefferson students live, and it's a quick hop on the Broad street line to take you straight to campus. So you can still enjoy all the things about center city that you could if you went to Jefferson. Some other Temple students prefer to live out near the suburbs and drive to Temple. But then you do have to worry about Parking (you can get a pass to park in Temple's parking lot) or worrying about Septa (generally very reliable). I wouldn't worry about safety if you went to Temple since you won't be living in the area, but keep in mind that there will be a commute involved. Drexel is in a very residential area, and students from Drexel live all around Philly depending on their preference (some center city, some suburbs, some right around campus). So basically Jefferson students are generally clustered right around campus whereas Temple & Drexel has students spread out more (a function of both the location and the fact that only Jeff has dorms).
Campus/Facilities
Jefferson has a new building that's very shiny and has dorms and apartments for students right next door (like literally). It has a very campus feel with a quad, with the library and dorms on one side, the clinical buildings on the other, and the hospital right across the street. You can roll out of bed and be in class literally five minutes later if you wanted. Temple's undergrad campus is a little bit of a distance away (it's walkable but due to the area, you do not want to) but the medical science building is right across the hospital, just like with Jefferson. Temple's new medical building is VERY shiny, and pretty much puts most other new buildings to shame (probably the best building I saw on my interview trail). Temple's anatomy lab and other spaces were excellent and top notch. Jefferson's classrooms were great but the anatomy lab was being renovated so I didn't get to see it, so I can't compare. Really, Temple spent like $200 million on that building and it shows. The only downside is that it's standalone from the university. However, remember that though the medical building and the hospital are right across the street, you will have to commute to get there, unlike at Jeff where the dorms, medical building and the hospital are right next to each other (assuming you live on campus at Jeff). Drexel's campus is even more fragmented because the medical science building and the hospital are not next to each other - there is a shuttle that goes back and forth between the two every 15 or 30 minutes. The day I took it, it took about 35 minutes to go from the campus to the hospital but it was rush hour and a lot of traffic so I'm sure it's shorter without that. The medical science building is very suburban and is decent but not new like Jeff or Temples.
Research/Clinical
Temple has clearly placed a lot of efforts in becoming more of a leader in this front as can be seen from their rise in rankings recently. Jefferson has more of an emphasis on Clinical and Translational research rather than bench research, so that's something to consider. That's not to say there won't be opportunities for any of the three at any of the three schools, but it's something to keep in mind. One thing that was very instructive was when I was at Jefferson's second look, the Dean said (and I'm paraphrasing) that "Some schools are almost disappointed if their students end up taking care of patients as their primary responsibility, but not here at Jefferson." I think that focus really shines in their third and fourth year (you're required to do much more than the typical med student, e.g get there before the resident, do a lot of intern level work, etc). That is not at all to imply that you won't be a great clinical at any of the either places. Temple is higher on the research ratings, while Jefferson students scored higher on residency program director's clinical aptitude ratings (US News). But both are close enough so that you're just basically just nitpicking. Temple sees fantastic trauma and serves a really needy population compared to the other two places. Drexel has the PBL curriculum option, which gives you more free time than the other two schools if you want to also do research while being in class, so that is a plus for them. Temple has more overall research money so you will have more choices in terms of which labs to pick. Jefferson has just introduced the College Within The College program, which allows you to pick either translational/clinical research or population health research, where you'll work with a mentor on a project over four years - meaning it's more tightly wound into the curriculum (instead of being on your own and being separate) and you can be guaranteed to have something publishable by the time you graduate (which is good for residencies). So they each have their own strengths in this regard. Jefferson allows you to complete all your 3rd and 4th year rotations in Delaware or Philadelphia, while Temple has more options in terms of Philadelphia, Pittsburgh, and a couple other places as well if you want to stay away from campus for the last two years.
Curriculum
Jefferson is H/P/F for the first two years, where Honors is like 90%, but it's set at that number so theoretically everyone could get honors or no one could (e.g you're not competing against anyone else). Temple is also exactly the same way. Drexel is H/P/F as well. Drexel has the advantage in terms of offering a PBL curriculum. Initially, I thought it might be the case of the 'blind leading the blind' where students would have no idea about what to do and would waste time. However, having sat in on a PBL classroom, that wasn't the case. The person leading the discussion was very knowledgeable and seemed to ask the perfect questions at the right time to kind of keep them on track, as well as give them things to discuss. It was fantastic because everyone would prepare their own homework and teach it to the rest of the class (if you can teach it, you know it really well). I wish the other two schools had this curriculum, personally. Otherwise, Temple and Jefferon are similar in this regard. All three schools have H/HP/P/F for the last two years.
Final Thoughts
I haven't looked at the match list for Drexel but both Jefferson's and Temple's were really good this past year and both will get you exactly where you want to go. Really it's going to be more up to you than your school, so pick your school based on other factors, not match lists. You can't go wrong, and if you do well at one school, chances are you would have done well at other schools as well.
For the sake of full disclosure, I picked Jefferson out of the three because of the A) Location, B) Ability to live on campus, C) College within a College, and D) the best 'feel' from faculty/students. I'm sure others picked Temple or Drexel for the exact same reasons.
This is a very subjective decision. Apply to all of them, check them out, and make your decision based on what you find important.
I hope this was helpful. I've lived in Philly forever, and I would be happy to answer any questions via PM or this thread.
for an interview! 
