Hey Anthrax, current M2 here. I want to add to some things that themockjock said, everything of which I agree with. (I'm not so much on the research bent so I have less experience there).
There are a couple of things that I think set Wayne apart from other schools. I say "I think" because I don't go to other schools, but just have to rely on what people say. I have a friend who goes to Michigan (also M2) who is impressed with the level of passion for outreach that a large part of our student body has. Some of this is driven by the cocurricular program, but I think a large segment of our student body would be doing a hefty amount of volunteering whether or not we were getting 4th year credit.
One of the cocurricular tracks is the one I'm involved in, MPAC -- Medicine and Political Action in the Community. In four years it has grown from 20 students to over 130 students enrolled in the program, and the director of it said that it's the first program of its kind at any medical school. We have discussions every month (different guest speakers every month on a variety of topics), and we get the opportunity to go on lobbying trips to Lansing and Washington DC (the DC trip travel expenses and some food expenses were paid by the school). The website is here if you want to take a look:
http://mpac.med.wayne.edu/
I would say another strength of Wayne is the depth and variety of pre-clinical volunteer opportunities. If you're the volunteering sort, there are definitely opportunities for you to be deeply involved with any number of organizations that have all been started by students, and continue to be run by students. It's a great way to service the citizens of the city of Detroit and beyond as well as practice some of the things you learn in your clinical medicine courses.
I would definitely say that the pre-clinical curriculum is pretty standard. Kind of meh. Some instructors are great and some instructors are not so great. But the student body (and the volunteer opportunities that come from a vocal and passionate student body) and the experience you gain in clinical years (not that I know that yet, but enough people have said so that I tend to believe them) is what really makes Wayne stand out.
Good luck!