The EL campus (about 200 students) has the largest class size and you'll be on a big beautiful campus at a big 10 university, meaning you'll have an insane amount of study spots. However, it is a college town with not much to do outside of the city (went to MSU for undergrad), so if you're trying to get away from that, then the EL campus might not be for you. Though, if you want to get involved in research, there are plenty of facilities there that will support you.
Regarding the Detroit campus (50ish students), it is a big city with plenty of things to do and great nightlife if that's your thing, and it has a team for every sport so you can always be getting last minute tickets to games and concerts post exam. While they don't have their own research facilities like EL does, you can get more involved in clinical research opportunities as Detroit is a hub for hospitals like the VA, DMC, and Henry ford, and you can even potentially get involved in the plethora of labs at WSUSOM. Plenty of MSUCOM Detroit students study at WSUSOM facilities. The area where the high schools are located (5 minute walk apart) are very safe and patrolled.
The macomb school (also 50ish students) is actually the nicest of all three of them, and everything you need is within a one mile radius from the school. Gyms, restaurants, grocery stores, and I have heard that students are very close to one another here as it has a very strong community feel. I don't know much about macomb, but I can tell it is the more quiet and least distracting location. As someone who went to school at both MSU and WSU, I can say that all three campuses and the students that I've spoken to at each location have loved their decisions. Good luck!