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Coming from a Des Moines native I would suggest trying to fly in there. Fares have been dropping ever since Southwest came into the picture, not a bad drive at all until you get about 20 miles north of KVegas, which still isn't bad.Depends. Do you want to fly straight into Kirksville on a 10 seat plane? If so, first fly into St. Louis and then take the flight into Kirksville. If not, I'd fly into Des Moines and just drive from there (~2.5 hrs.).
When I interviewed, I flew into STL and then drove (~3.25 hrs.) from there because I didn't want to get on that small plane. Didn't think about flying into Des Moines at the time, but it's definitely closer and it's a smaller airport so it's easier to navigate.