To OOS rejectees:
If IU is one of your top choices, you can always appeal. Almost all medical schools are receptive to such letters -- at least when you have grounds for appeal. When your appeal has legitimate traction, such appeals are actually quite effective because they demonstrate your serious interest in the school. I was initially rejected by the school I at which I am matriculating this year. True story.
Most people just accept the rejection and move on. If it's "not worth the effort" to you, then live with their decision. Just know that it isn't exactly as "final" as most people assume. No guarantees, but it's still an option.