There will be one station where you will be asked the classic "why do you want to be a doctor?" question.
I can't remember specifically if they have access to our file ahead of time. I'd reckon that if they are going to ask you anything related to your file that is in addition to the prompt it'll very much be in a conversational manner. Honestly though, you have very limited time in each station (8 minutes once you enter) that the focus should, and will be on the prompt. Any extra time will largely be used to ask follow up questions about your answer, or they may just ask about you because they are curious and want to know more. On some stations I even put them in the hot seat and asked them about what they do at duke and their affiliations.